Entité de rattachement
ChemBioM Chimie et Biologie des Microorganismes
Thème interdisciplinaire de recherche
Biochimie
Spécialité
Peptides antimicrobiens, Microcines, Peptides lasso, HPLC, Spectrométrie de masse

Contact

Courriel
christophe.goulard [at] mnhn.fr
Téléphone
01 40 79 48 98
Adresse(s)

43 rue Buffon

24 allée des crapauds
75005 Paris

Présentation

Activités de recherche

Production, purification et caractérisation biochimique et physicochimique de peptides et protéines, en particulier peptides antimicrobiens de bactéries.

Publications

2025
  • Boudrioua Abdelhakim, Baëtz Benjamin, Desmadril Solenn, Goulard Christophe, Groo Anne-Claire, Lombard Carine, Gueulle Sabrina, Marugan Marie, Malzert-Fréon Aurélie, Hartke Axel, Li Yanyan & Giraud Caroline, 2025 — Lasso peptides sviceucin and siamycin I have anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens. iScience , , p. 111922
    ISSN
    2589-0042
    https://dx.doi.org/10.1016/j.isci.2025.111922
2018
  • Mevaere Jimmy, Goulard Christophe, Schneider Olha, Sekurova Olga N., Ma Haiyan, Zirah Séverine, Afonso Carlos, Rebuffat Sylvie, Zotchev Sergey B. & Li Yanyan, 2018 — An orthogonal system for heterologous expression of actinobacterial lasso peptides in Streptomyces hosts. Scientific Reports vol. 8, n° 1, p. 8232
    ISSN
    2045-2322
    https://dx.doi.org/10.1038/s41598-018-26620-0
  • Riera Elisabeth, Lamy Dominique, Goulard Christophe, Francour Patrice & Hubas Cédric, 2018 — Biofilm monitoring as a tool to assess the efficiency of artificial reefs as substrates: Toward 3D printed reefs. Ecological Engineering vol. 120, , p. 230-237
    ISSN
    09258574
    https://dx.doi.org/10.1016/j.ecoleng.2018.06.005
2017
  • Besse A., Vandervennet M., Goulard C., Peduzzi J., Isaac S., Rebuffat S. & Carre-Mlouka A., 2017 — Halocin C8: an antimicrobial peptide distributed among four halophilic archaeal genera: Natrinema, Haloterrigena, Haloferax, and Halobacterium. Extremophiles : life under extreme conditions vol. 21, n° 3, p. 623-638
    ISSN
    1433-4909 (Electronic) 1431-0651 (Linking)
    https://dx.doi.org/10.1007/s00792-017-0931-5
2016
  • Petit Vanessa W., Rolland Jean-Luc, Blond Alain, Cazevieille Chantal, Djediat Chakib, Peduzzi Jean, Goulard Christophe, Bachère Evelyne, Dupont Joëlle, Destoumieux-Garzón Delphine & Rebuffat Sylvie, 2016 — A hemocyanin-derived antimicrobial peptide from the penaeid shrimp adopts an alpha-helical structure that specifically permeabilizes fungal membranes. Biochimica et Biophysica Acta (BBA) - General Subjects vol. 1860, n° 3, p. 557-568
    ISSN
    03044165
    https://dx.doi.org/10.1016/j.bbagen.2015.12.010
2015
  • Li Yanyan, Ducasse Rémi, Zirah Séverine, Blond Alain, Goulard Christophe, Lescop Ewen, Giraud Caroline, Hartke Axel, Guittet Eric, Pernodet Jean-Luc & Rebuffat Sylvie, 2015 — Characterization of Sviceucin from Streptomyces Provides Insight into Enzyme Exchangeability and Disulfide Bond Formation in Lasso Peptides. ACS Chemical Biology vol. 10, n° 11, p. 2641-2649
    ISSN
    1554-8929, 1554-8937
    https://dx.doi.org/10.1021/acschembio.5b00584
2014
  • Mathavan I., Zirah S., Mehmood S., Choudhury H. G., Goulard C., Li Y., Robinson C. V., Rebuffat S. & Beis K., 2014 — Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides. Nature chemical biology vol. 10, n° 5, p. 340-2
    ISSN
    1552-4469 (Electronic) 1552-4450 (Linking)
    https://dx.doi.org/10.1038/nchembio.1499
2012
  • Ducasse Rémi, Yan Kok-Phen, Goulard Christophe, Blond Alain, Li Yanyan, Lescop Ewen, Guittet Eric, Rebuffat Sylvie & Zirah Séverine, 2012 — Sequence Determinants Governing the Topology and Biological Activity of a Lasso Peptide, Microcin J25. ChemBioChem vol. 13, n° 3, p. 371-380
    ISSN
    14394227
    https://dx.doi.org/10.1002/cbic.201100702
  • Yan K. P., Li Y., Zirah S., Goulard C., Knappe T. A., Marahiel M. A. & Rebuffat S., 2012 — Dissecting the maturation steps of the lasso peptide microcin J25 in vitro. Chembiochem vol. 13, n° 7, p. 1046-52
    ISSN
    1439-7633 (Electronic) 1439-4227 (Linking)
    https://dx.doi.org/10.1002/cbic.201200016
Voir toutes les publications