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Novel functions and structures of heterocyclic antibacterial peptides
Chimie
Séminaire :
Novel functions and structures of heterocyclic antibacterial peptides
le 5 juin 2018 à 11h30

Informations pratiques
Bioinformatics analysis indicates that heterocycle-containing bioactive peptides are widespread in bacteria but their structures and functions remains largely unknown. The prototypical heterocycle peptide, microcin B17, targets the DNA gyrase, an essential bacterial enzyme. I will present data on genome-mining of new heterocycle peptide clusters and show that minimal changes of their scaffold can allow them to inhibit completely different targets, including the bacterial ribosome. The results underscore the potential of heterocyclic peptides as versatile scaffolds for rational drug design.
Publié le : 17/05/2018 à 15:43 - Mis à jour le : 17/05/2018 à 15:57
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