Affiliation entity
BIM Biochemistry of Microbial Interactions
Interdisplinary research theme
Process of diatoms’ adhesion: toward the elucidation of the molecular mechanisms
Adhesion, Diatom, Transcriptomics, Metabolomics, Multivariate statistics, Antifouling


Social networks
andrea.castaldi1 [at]
01 40 79 31 44

43 rue Buffon

24 allée des crapauds

75005 Paris


Research activities

Diatoms are, along with bacteria, the first organisms to colonize submerged structures, causing fouling problems. Latest works on the design of new non-toxic antifoulings are based on strategies that modify the coatings. Our approach, which breaks with these previous studies, proposes to determine whether diatoms have adhesion mechanisms that adapt to the substrate encountered.


Our project will focus on highlighting potential variability in the metabolome of the diatoms: Phaeodactylum tricornutum, Cylindrotheca closterium and Amphora coffaeformis, depending on their ability to adhere to three different substrates (glass, polystyrene, polydimethylsiloxane). Two complementary approaches will be developed using modern and innovative methods such as genetics with transcriptomic analyses and metabolomics (mass spectrometry, nuclear magnetic resonance and multivariate statistical analyses) with the study of molecular networks, in order to identify the genes and the molecules produced on specific coatings, respectively.


This work will permit us to describe and understand the molecular mechanisms of diatom adhesion, to define the characteristics of antifouling surfaces, and to identify the metabolites involved in adhesive phenomena. This study will contribute to the innovation in the design of antifouling materials by considering the reality of the diatom adhesion process.


  • Wang Huibin, Halary Sébastien, Duval Charlotte, Bernard Cécile, Troussellier Marc, Beniddir Mehdi A., Brunel Jean-Michel, Castaldi Andrea, Caudal Flore, Golléty Claire, Martin Coralie, Bourguet-Kondracki Marie-Lise & Duperron Sébastien, 2023Diversity, metabolome profiling and bioactivities of benthic filamentous cyanobacteria isolated from coastal mangroves of Mayotte. Frontiers in Marine Science vol. 10, ,
  • Castaldi Andrea, Teta Roberta, Esposito Germana, Beniddir Mehdi A., De Voogd Nicole J., Duperron Sébastien, Costantino Valeria & Bourguet-Kondracki Marie-Lise, 2022Computational Metabolomics Tools Reveal Subarmigerides, Unprecedented Linear Peptides from the Marine Sponge Holobiont Callyspongia subarmigera. Marine Drugs vol. 20, n° 11, p. 673