Affiliation entity
ChemBioM Chemistry and Biology of Microorganisms
Researches
Accreditation to supervise research

Contact

E-mail
yanyan.li [at] mnhn.fr
Phone
01 40 79 57 91
Address(es)

43 rue Buffon

24 allée des crapauds
75005 Paris

Teaching

  • TD Master MNHN « Molécules et Cibles Thérapeutique » : Genome mining of microbial secondary metabolites
  • École thématique « Multifonctions de peptides antimicrobiens », 14-18 mars 2016, Quimper, Fran

Presentation

Publications

2025
  • Boudrioua Abdelhakim, Baëtz Benjamin, Desmadril Solenn, Goulard Christophe, Groo Anne-Claire, Lombard Carine, Gueulle Sabrina, Marugan Marie, Malzert-Fréon Aurélie, Hartke Axel, Li Yanyan & Giraud Caroline, 2025 — Lasso peptides sviceucin and siamycin I have anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens. iScience , , p. 111922
    ISSN
    2589-0042
    https://dx.doi.org/10.1016/j.isci.2025.111922
  • Klaubert Tim J., Gellner Jonas, Bernard Charles, Effert Juliana, Lombard Carine, Kaila Ville R. I., Bode Helge B., Li Yanyan & Groll Michael, 2025 — Molecular basis for azetidine-2-carboxylic acid biosynthesis. Nature Communications vol. 16, n° 1, p. 1348
    ISSN
    2041-1723
    https://dx.doi.org/10.1038/s41467-025-56610-6
2024
  • Baquero Fernando, Beis Konstantinos, Craik David J., Li Yanyan, Link A. James, Rebuffat Sylvie, Salomón Raúl, Severinov Konstantin, Zirah Séverine & Hegemann Julian D., 2024 — The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide. Natural Product Reports vol. 121, , e2408304121
    ISSN
    1460-4752
    https://dx.doi.org/10.1039/D3NP00046J
  • Effert Juliana, Westphalen Margaretha, Calderari Andrea, Shi Yi-Ming, Elamri Isam, Najah Soumaya, Grün Peter, Li Yanyan, Gruez Arnaud, Weissman Kira J. & Bode Helge B, 2024 — Pyrrolizwilline, a unique bacterial alkaloid assembled by a nonribosomal peptide synthetase and non-enzymatic dimerization. Angewandte Chemie International Edition vol. 63, , e202411258
    ISSN
    1521-3773
    https://dx.doi.org/10.1002/anie.202411258
  • Leprevost Laura, Jünger Sophie, Lippens Guy, Guillaume Céline, Sicoli Giuseppe, Oliveira Lydie, Falcone Enrico, de Santis Emiliano, Rivera-Millot Alex, Billon Gabriel, Stellato Francesco, Henry Céline, Antoine Rudy, Zirah Séverine, Dubiley Svetlana et al., 2024 — A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stress. Proceedings of the National Academy of Sciences vol. 121, n° 49, e2408304121
    https://dx.doi.org/10.1073/pnas.2408304121
  • Schiefelbein Kevin, Lang Jakob, Schuster Matthias, Grigglestone Claire E., Striga Robin, Bigler Laurent, Schuman Meredith C., Zerbe Oliver, Li Yanyan & Hartrampf Nina, 2024 — Merging Flow Synthesis and Enzymatic Maturation to Expand the Chemical Space of Lasso Peptides. Journal of the American Chemical Society vol. 146, n° 25, p. 17261-17269
    ISSN
    0002-7863
    https://dx.doi.org/10.1021/jacs.4c03898
2023
  • Aggarwal Shifu, Huang Elaine, Do Hackwon, Makthal Nishanth, Li Yanyan, Bapteste Eric, Lopez Philippe, Bernard Charles & Kumaraswami Muthiah, 2023 — The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes. Nature Communications vol. 14, n° 1, p. 5947
    ISSN
    2041-1723
    https://dx.doi.org/10.1038/s41467-023-41719-3
  • Bernard Charles, Li Yanyan, Lopez Philippe & Bapteste Eric, 2023 — Large-Scale Identification of Known and Novel RRNPP Quorum-Sensing Systems by RRNPP_Detector Captures Novel Features of Bacterial, Plasmidic, and Viral Coevolution. Molecular Biology and Evolution vol. 40, n° 4, msad062
    ISSN
    1537-1719
    https://dx.doi.org/10.1093/molbev/msad062
2022
  • Madi-Moussa Désiré, Deracinois Barbara, Teiar Radja, Li Yanyan, Mihasan Marius, Flahaut Christophe, Rebuffat Sylvie, Coucheney Françoise & Drider Djamel, 2022 — Structure of Lacticaseicin 30 and Its Engineered Variants Revealed an Interplay between the N-Terminal and C-Terminal Regions in the Activity against Gram-Negative Bacteria. Pharmaceutics vol. 14, n° 9, p. 1921
    ISSN
    1999-4923
    https://dx.doi.org/10.3390/pharmaceutics14091921
  • Rivas Arenas Laura A., de Paiva Fernanda C. R., de O． Rossini Nicolas, Li YanYan, Spencer Jonathan, Leadlay Peter & Dias Marcio V. B., 2022 — Crystal structure of BtrK, a decarboxylase involved in the (S)-4-amino-2-hydroxybutyrate (AHBA) formation during butirosin biosynthesis. Journal of Molecular Structure vol. 1267, , p. 133576
    ISSN
    0022-2860
    https://dx.doi.org/10.1016/j.molstruc.2022.133576
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