Interdisplinary research theme
physical-chemistry, biophysics and biochemistry of natural products, research of correlations between physico-chemical properties of natural products and their biological activities in vitro and in vivo
Researches
Accreditation to supervise research

Contact

E-mail
rene-victor.bensasson [at] mnhn.fr
Phone
01 40 79 36 92
Address(es)

43 rue Buffon

24 allée des crapauds

75005 Paris

Presentation

emeritus director of research at the" Centre National de la Recherche Scientifique"

Research activities

From 1955 to1964: Chemistry induced by ionizing radiations, polymerisations induced by X- and g- rays.



From 1964 to 2016: Two main direction of studies:

1) Using mainly two complementary time-resolved spectroscopic methods, laser flash photolysis and pulse radiolysis,  our group has investigated :

(i) the primary species (Excited States and Radicals)  involved in Vision, Photosynthesis, Photodamage of Nucleic Acids and Photochemotherapies

(ii) the spectroscopic, photophysical, and photochemical properties of fullerenes C60, C70 and derivatives

2) Using mainly quantum chemical approaches, our group has investigated redox regulation processes involved in

(i) Cancer chemoprotection in vivo and in cellular models

(ii) Control of genetic expression

(a) induction of a prototypic cancer-rotective enzyme, quinone reductase (NQO1)

(b) inhibition of topoisomerase

(c) inhibition of angiogenesis

(d) inhibition of cellular inflammatory response

(iii) Anti-inflammation chemoprotection in vivo

 

Publications :

- 162 publications

- Livres

Co-auteur de livres :

  • R.V. BENSASSON, E.J. LAND & T.G. TRUSCOTT. Flash photolysis and Pulse radiolysis. Contributions to the Chemistry of Biology and Medicine. Pergamon Press, 226 pages, Oxford (1983) ISBN 0-08024949-3. Translated in Russian by David Nokogosyan for the Editions MIR, Moscow, 1987.

     
  • R.V. BENSASSON, E.J. LAND & T.G. TRUSCOTT. Excited states and free radicals in biology and medicine. Contributions from flash photolysis and pulse radiolysis. Oxford University Press , 440 pages, 89 illustrations, Oxford, (1993) ISBN 0-19-855560-1

Co-éditeur de livres :

  • R.V. BENSASSON, G. JORI, E.J. LAND & T.G. TRUSCOTT. Primary photoprocesses in biology and medicine. Plenum Press, series A life Science New York and London (1985) 85. ISBN 0-306-41930-0.



Quelques articles récents représentatifs de nos directions de travail :

 

  • Zhu X, Quaranta A, Bensasson RV, Sologloub M, Zhang Y. 2017. Secondary-Rim γ-Cyclodextrin Functionalization to Conjugate with C60: Improved Efficacy as a Photosensitizer. Chemistry A European Journal. DOI: 10.1002/chem.201700782

     
  • Bensasson RV, Dinkova-Kostova AT, Zheng S, Saito A, Li W, Zoete V, Honda T. 2016. Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme. Bioorganic & Medicinal Chemistry Letters, 26, 4345-4349. DOI: 10.1016/j.bmcl.2016.07.028

     
  • Quaranta A, Huanhuan QU, Vencel T, Zhang Y, Leibl W, Leach S, Bensasson RV.2014. Photophysical properties in aqueous solutions of C60 embedded in 2:1  cyclodextrin/[60]fullerene inclusion complexes. Chemical Physics Letters, 614, 234–237.

     
  • Bensasson RV, Sowlati S, Zoete V, Dauzonne D, and Matta CF. 2013. Physicochemical properties of exogenous molecules correlated with their biological efficacy as protectors against carcinogenesis and inflammation. International Reviews in Physical Chemistry, 32, 393–434

     
  • Bensasson RV, Zoete V, Jossang A, Bodo B, Arimondo PB, Land EJ. 2011. Potency to inhibit human DNA topoisomerase I by flavones assessed through physico-chemical parameters. Free Radic. Biol. Med., 51, 1406-1410. DOI:10.1016/j.freeradbiomed.2011.06.021

     
  • Bensasson RV, Berthier G, Zoote V, Talalay P, Dinkova-Kostova A. 2010. Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index. Chem. Biol. Interact. 186, 118–126. DOI:10.1016/j.cbi.2010.04.026

     
  • Bensasson RV, Berthier G, Zoote V. 2009 Comment on “Assessing the Efficacy of Nonsteroidal Anti-Inflammatory Drugs Through the Quantum Computation of Molecular Ionization Energies”. J. Phys. Chem. A, 113, 12337–12338. DOI:10.1021/jp9074652

     
  • Bensasson RV, Zoete V, Dinkova-Kostova AT, Talalay P. 2008. Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols. Chem. Res. Toxicol. 21, 805–812. DOI:10.1021/tx7002883

 

Other activites

Member of the Academia Europaea elected in 1989 (section: Biophysics)

Membre d’Honneur de la Société Française de Photobiologie since the 1rst of january 2013

Member of the Editorial Board of

  • Fullerenes, nanotubes and carbon nanostructures (DEKKER)
  • Acta Laser Biology Sinica (Genetics Society of China)
  • Journal of Photochemistry & Photobiology B: Biology (ELSEVIER)
  • Biomedicine & Pharmacotherapy. (ELSEVIER)

 

Publications

2017
  • Zhu Xiaolei, Quaranta Annamaria, Bensasson René V., Sollogoub Matthieu & Zhang Yongmin, July 2017Secondary-Rim γ-Cyclodextrin Functionalization to Conjugate with C _{\textrm{60}} : Improved Efficacy as a Photosensitizer. Chemistry - A European Journal vol. 23, n° 40, p. 9462-9466
    ISSN
    09476539
2016
  • Bensasson René V., Dinkova-Kostova Albena T., Zheng Suqing, Saito Akira, Li Wei, Zoete Vincent & Honda Tadashi, September 2016Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme. Bioorganic \& Medicinal Chemistry Letters vol. 26, n° 17, p. 4345-4349
    ISSN
    0960894X
2014
  • Quaranta Annamaria, Qu Huanhuan, Vencel Thomas, Zhang Yongmin, Leibl Winfried, Leach Sydney & Bensasson René V., October 2014Photophysical properties in aqueous solutions of C 60 embedded in 2:1 γ-cyclodextrin/[60]fullerene inclusion complexes. Chemical Physics Letters vol. 614, , p. 234-237
    ISSN
    00092614
2013
  • Bensasson René V., Sowlati-Hashjin Shahin, Zoete Vincent, Dauzonne Daniel & Matta Chérif F., September 2013Physicochemical properties of exogenous molecules correlated with their biological efficacy as protectors against carcinogenesis and inflammation. International Reviews in Physical Chemistry vol. 32, n° 3, p. 393-434
    ISSN
    0144-235X, 1366-591X
2011
  • Bensasson René V., Zoete Vincent, Jossang Akino, Bodo Bernard, Arimondo Paola B. & Land Edward J., October 2011Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters. Free Radical Biology and Medicine vol. 51, n° 7, p. 1406-1410
    ISSN
    08915849
2010
  • Bensasson René V., Zoete Vincent, Berthier Gaston, Talalay Paul & Dinkova-Kostova Albena T., July 2010Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index. Chemico-Biological Interactions vol. 186, n° 2, p. 118-126
    ISSN
    00092797