Affiliation entity
PPL Parasites and Free-living Protists
Host-Parasite interactions, Helminths, Nematodes, Filariae, Wolbachia, Immunology, Molecular and Cellular Biology


Social networks
cmartin [at]
+33 1 40 79 34 96

61 rue Buffon (CP52)

75005 Paris

Responsibilities inside unit

Team leader of the PPL team

Responsibilities outside unit

Elected member of the AVIV department council (from 2017)

Member of the scientific council of the DIM “One Health” (from 2017)

Membre of the Comitee ANR CES 18 Biomedical Innovation  (from 2020)

Member of the scientific council  of the MNHN program  "ATM Blanches" (2016-2018)

Coordinator of the MNHN program "ATM Microorganismes" (2014-2015)

President of the French Society of Parasitology (2018-2020)




  • Professor, Muséum National d'Histoire Naturelle, France [2021 - ... ]
  • CR1, National Institute for Health and Medical Research (INSERM) Muséum National d'Histoire Naturelle, France [2005 - 2021 ]
  • Research Associate "Vessels and Blood Institute", Hopital Lariboisière, Paris , France [2004 - 2005]
  • Wellcome Trust Postdoctoral Research Associate Imperial College, London, UK [2001-2004]


HDR (Habilitation à Diriger des Recherches): University of Paris VI, France [2007]

PhD : University of Paris VI, France [2001]


Research activities

My area of expertise deals with filarial parasites (Onchocercidae nematodes) and their Wolbachia bacterial endosymbionts. The host range of these nematodes covers all terrestrial vertebrates worldwide. Several filarial species are responsible for tropical diseases agents, such as lymphatic filariasis and onchocerciasis ("river blindness").

Another interesting particularity of filaria is that they can harbor an endosymbiotic bacteria Wolbachia, also present in arthropods. This bacteria is now a target for therapeutic drugs, as the filaria can not survive without their bacterial endosymbionts.

We also also interested in this tripartite symbiotic association: an eukaryotic microorganism - Onchocercidae-, a bacterium endosymbionte - Wolbachia - and an evolved organism - a terrestrial vertebrate - and in the processes of adaptation at the molecular and cellular level of these partners. More specifically we study:

1. the phylogenetic relationships between filaria and bacteria

2. the migrations and the development of the filaria and their interactions with the cellular (granulocytes, macrophages) and tissular (lymthatic, blood and lung) environment of their vertebrate host

3. the immune responses of the vertebrate specific to the bacteria and those specific to thz filaria, as well as their modifications by agents of stress, such as vaccination processes, adjuvants or anti-filaria/anti-bacteria treatments

We have developed a mouse model of filariasis (Litomosoides sigmodontis) that we use routinely for questions regarding points 2 and 3.

Currently we are interested in the coevolutionnary history of bird filariae and the coevolution between collemboles and Wolbachia (collab. C. d'Haesse, UMR7179) and we study the chronic pulmonary inflammation in the model of filariosis using  L. sigmodontis.


Queue et spicules d'une filaire adulte mâle L. sigmodontis âgé de 60 jours © Landmann et Martin

Queue et spicules d'une filaire adulte mâle L. sigmodontis âgé de 60 jours © Landmann et Martin

© Landmann et Martin


Topologie de Wolbachia © MNHN

Topologie de Wolbachia, une bactérie endosymbionte des filaires er des arthropodes (adaptée de Lefoulon et al. (2016), PeerJ 4:e1840)





Remion E, Gal J, Chaouch S, Rodrigues J, Lhermitte-Vallarino N, Alonso J, Kohl L, Hübner MP, Fercoq F, Martin C. Unbalanced Arginine pathway and altered maturation of pleural macrophages in Th2-deficient mice during Litomosoides sigmodontis filarial infection. Front Immunol. 2022 Oct 24;13:866373. doi: 10.3389/fimmu.2022.866373. eCollection 2022. PMID: 36353644.

Hawryluk N, Robinson D, Shen Y, Kyne G, Bedore M, Menon S, Canan S, von Geldern T, Townson S, Gokool S, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Dalvie D, Specht S, Hübner MP, Scandale I. Zoonotic infection caused by Onchocerca japonica (Nematoda: Filarioidea) in a 69-year-old woman in Kanto Region, Eastern Honshu, Japan. J Med Chem. 2022 Aug 25;65(16):11388-11403. doi: 10.1021/acs.jmedchem.2c00960. Epub 2022 Aug 16. PMID: 35972896

Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections. Okazaki D, Fukuda M, Hebisawa A, Uni S, Junker K, Suzuki Y, Nakano M, Agatsuma T, Hasegawa H, Yamada M, Nakatani J, Hara T, Martin C, Kimura D, Takaoka H. Parasitol Int. 2022 Dec;91:102643. doi: 10.1016/j.parint.2022.102643. Epub 2022 Aug 9. PMID: 35961578
Hawryluk N, Zhiru L, Carlow C, Gokool S, Townson S, Kreiss T, Chojnowski A, Prorok M, Siekierka J, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Canan S, Khetani V, Zeldis J, Specht S, Hübner MP, Scandale I. Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization. Int J Parasitol Drugs Drug Resist. 2022 Aug;19:89-97. doi: 10.1016/j.ijpddr.2022.06.002. Epub 2022 Jun 23.

S. Uni, A. SyihanMat Udin, P. EanTan, J. Rodrigues, C. Martin, K. Junker, T. Agatsuma, V. Lun Low, Y. Ai-Lian Lim, W. Saijuntha, H. Omar, N. Afiquah Zainuri, M. Fukuda, D. Kimura, M. Matsubayashi, S. Uga, H. Takaoka, M. Sofian Azirun, R. Ramli. Description and molecular characterisation of Pelecitus copsychi Uni, Mat Udin & Martin n. sp. (Nematoda: Onchocercidae) from the white-rumped shama Copsychus malabaricus (Scopoli) (Passeriformes: Muscicapidae) of Pahang, Malaysia. Current Research in Parasitology & Vector-Borne Diseases, Volume 2, 2022, 100078.


Ehrens A, Lenz B, Neumann AL, Giarrizzo S, Reichwald JJ, Frohberger SJ, Stamminger W, Buerfent BC, Fercoq F, Martin C, Kulke D, Hoerauf A, Hübner MP. Microfilariae Trigger Eosinophil Extracellular DNA Traps in a Dectin-1-Dependent Manner. Cell Rep. 2021 Jan 12;34(2):108621. doi: 10.1016/j.celrep.2020.108621.

Borba VH, Martin C, Machado-Silva JR, Xavier SCC, de Mello FL, Iñiguez AM. Machine learning approach to support taxonomic species discrimination based on helminth collections data. Parasit Vectors. 2021 May 1;14(1):230.  doi: 10.1186/s13071-021-04721-6.



Card C, Wilson DS, Hirosue S, Rincon-Restrepo M, de Titta A, Güç E, Martin C, Bain O, Swartz MA, Kilarski WW.  Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers. Sci Rep. 2020 Jan 23;10(1):1055. doi: 10.1038/s41598-020-57995-8.

Fercoq F, Remion E, Vallarino-Lhermitte N, Alonso J, Raveendran L, Nixon C, Le Quesne J, Carlin LM, Martin C. Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents. Parasit Vectors. 2020 Nov 7;13(1):551. doi: 10.1186/s13071-020-04428-0.

Frohberger SJ, Fercoq F, Neumann AL, Surendar J, Stamminger W, Ehrens A, Karunakaran I, Remion E, Vogl T, Hoerauf A, Martin C, Hübner MP.  S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis. PLoS Negl Trop Dis 2020 14(2): e0008119.

Gaillard CM, Pion SD, Hamou H, Sirima C, Bizet C, Lemarcis T, Rodrigues J, Esteban A, Peeters M, Mpoudi Ngole E, Mombo I, Liégeois F, Martin C, Boussinesq M, Locatelli S. Detection of DNA of filariae closely related to Mansonella perstans in faecal samples from wild non-human primates from Cameroon and Gabon. Parasit Vectors. 2020 Jun 16;13(1):313. doi: 10.1186/s13071-020-04184-1.

Hennocq Q, Helary A, Debelmas A, Monsel G, Labat A, Bertolus C, Martin C, Caumes E. Oral migration of Dirofilaria repens after creeping dermatitis. Parasite. 2020; 27:16. doi: 10.1051/parasite/2020015. Epub 2020 Mar 18.

Hübner MP, Martin C, Specht S, Koschel M, Dubben B, Frohberger SJ, Ehrens A, Fendler M, Struever D, Mitre E, Vallarino-Lhermitte N, Gokool S, Lustigman S, Schneider M, Townson S, Hoerauf A, Scandale I. Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro. PLoS Negl Trop Dis. 2020 Jul 6;14(7):e0008427. doi: 10.1371/journal.pntd.0008427. eCollection 2020 Jul.

Lefoulon E, Clark T, Guerrero R, Cañizales I, Cardenas-Callirgos JM, Junker K, Vallarino-Lhermitte N, Makepeace BL, Darby AC, Foster JM, Martin C, Slatko BE. Diminutive, degraded but dissimilar: Wolbachia genomes from filarial nematodes do not conform to a single paradigm. Microb Genom. 2020 Dec 9. doi: 10.1099/mgen.0.000487.

Uni S, Mat Udin AS, Agatsuma T, Junker K, Saijuntha W, Bunchom N, Fukuda M, Martin C, Lefoulon E, Labat A, Khan FAA, Low VL, Cheah PL, Lim YA, Ramli R, Belabut DM, Zainuri NA, Matsubayashi M, Omar H, Bhassu S, Uga S, Hashim R, Takaoka H, Azirun MS. 2020. Description, molecular characteristics and Wolbachia endosymbionts of Onchocerca borneensis Uni, Mat Udin & Takaoka n. sp. (Nematoda: Filarioidea) from the Bornean bearded pig Sus barbatus Müller (Cetartiodactyla: Suidae) of Sarawak, Malaysia. Parasit Vectors. 2020 Feb 6;13(1):50. doi: 10.1186/s13071-020-3907-8.


Fercoq F, Remion E, Frohberger SJ, Vallarino-Lhermitte N, Hoerauf A, Le Quesne J, Landmann F, Hübner MP, Carlin LM, Martin C. IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation. PLoS Negl Trop Dis. 2019 Aug 30;13(8):e0007691. doi: 10.1371/journal.pntd.0007691. eCollection 2019 Aug.

Kilarski WW, Martin C, Pisano M, Bain O, Babayan SA, Swartz MA. 2019. Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels. Nat Commun. 2019 Jul 1;10(1):2895. doi: 10.1038/s41467-019-10675-2.

Quintana JF, Kumar S, Ivens A, Chow FWN, Hoy AM, Fulton A, Dickinson P, Martin C, Taylor M, Babayan SA, Buck AH. Comparative analysis of small RNAs released by the filarial nematode Litomosoides sigmodontis in vitro and in vivo. PLoS Negl Trop Dis. 2019 Nov 26;13(11):e0007811. doi: 10.1371/journal.pntd.0007811. eCollection 2019 Nov.

Regnier A, Martin C, Semin MO, Lienard E, Geffre A, Douet JY, Raymond-Letron I. (2019) Subconjunctival nodule due to Setaria equina erratic migration in a horse: First case report. Vet Ophthalmol. 2019 Nov;22(6):921-927. doi: 10.1111/vop.12675. Epub 2019 May 2.

Mirzaei M, Ghahvei Y, Lefoulon E, Lia RP, Otranto D, Martin C, Sazmand A. (2019) Morphological and molecular characterization of Onchocerca fasciata (Nematoda, Onchocercidae) from dromedary camels (Camelus dromedarius) in Iran. Parasite. 2018;25:50. doi: 10.1051/parasite/2018045. Epub 2018 Sep 20.


Latrofa MS, Annoscia G, Colella V, Cavalera MA, Maia C, Martin C, Šlapeta J, Otranto D. (2018)  A real-time PCR tool for the surveillance of zoonotic Onchocerca lupi in dogs, cats and potential vectors. PLoS Negl Trop Dis. 2018 Apr 4;12(4):e0006402. doi: 10.1371/journal.pntd.0006402. eCollection 2018 Apr.

Colella V, Maia C, Pereira A, Gonçalves N, Caruso M, Martin C, Cardoso L, Campino L, Scandale I, Otranto D. 2018. Evaluation of oxfendazole in the treatment of zoonotic Onchocerca lupi infection in dogs. PLoS Negl Trop Dis. Jan 29;12(1):e0006218. doi: 10.1371/journal.pntd.0006218. eCollection 2018 Jan.

Specht S, Pfarr KM, Arriens S, Hübner MP, Klarmann-Schulz U, Koschel M, Sternberg S, Martin C, Ford L, Taylor MJ, Hoerauf A. 2018.  Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model. PLoS Negl Trop Dis. 2018 Jan 4;12(1):e0006116. doi: 10.1371/journal.pntd.0006116. eCollection 2018 Jan .


Karadjian G, Fercoq F, Pionnier N, Vallarino-Lhermitte N, Lefoulon E, Nieguitsila A, Specht S, Carlin LM, Martin C. 2017.  Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. PLoS Negl Trop Dis. May 9;11(5):e0005596.

Uni S, Mat Udin AS, Agatsuma T, Saijuntha W, Junker K, Ramli R, Omar H, Lim YA, Sivanandam S, Lefoulon E, Martin C, Belabut DM, Kasim S, Abdullah Halim MR, Zainuri NA, Bhassu S, Fukuda M, Matsubayashi M, Harada M, Low VL, Chen CD, Suganuma N, Hashim R, Takaoka H, Azirun MS. 2017.  Morphological and molecular characteristics of Malayfilaria sofiani Uni, Mat Udin & Takaoka n. g., n. sp. (Nematoda: Filarioidea) from the common treeshrew Tupaia glis Diard & Duvaucel (Mammalia: Scandentia) in Peninsular Malaysia. Parasit Vectors. Apr 20;10(1):194.

Lefoulon E, Giannelli A, Makepeace BL, Mutafchiev Y, Townson S, Uni S, Verocai GG, Otranto D, Martin C. 2017.   Whence river blindness? The domestication of mammals and host-parasite co-evolution in the nematode genus Onchocerca. Int J Parasitol. Jul;47(8):457-470. doi: 10.1016/j.ijpara.2016.12.009.

Lia RP, Mutafchiev Y, Veneziano V, Giannelli A, Abramo F, Santoro M, Latrofa MS, Cantacessi C, Martin C, Otranto D, Bertuglia A, Riccio B. 2017. Filarial infection caused by Onchocerca boehmi (Supperer, 1953) in a horse from Italy. Parasitol Res. Jan;116(1):191-198.


Pionnier N, Brotin E, Karadjian G, Hemon P, Gaudin-Nomé F, Vallarino-Lhermitte N, Nieguitsila A, Fercoq F, Aknin ML, Marin-Esteban V, Chollet-Martin S, Schlecht-Louf G, Bachelerie F, Martin C. 2016. Neutropenic mice provide insight into the role of skin-Infiltrating Neutrophils in the host protective Immunity against Filarial Infective Larvae. PLoS Negl Trop Dis. Apr 25;10(4):e0004605

Lefoulon E, Bain O, Makepeace BL, d'Haese C, Uni S, Martin C, Gavotte L. 2016. Breakdown of coevolution between symbiotic bacteria Wolbachia and their filarial hosts. PeerJ. Mar 28;4:e1840.


Lefoulon E, Bain O, Bourret J, Junker K, Guerrero R, Cañizales I, Kuzmin Y, Satoto TB, Cardenas-Callirgos JM, de Souza Lima S, Raccurt C, Mutafchiev Y, Gavotte L, Martin C. 2015. Shaking the Tree: Multi-locus Sequence Typing Usurps Current Onchocercid (Filarial Nematode) Phylogeny. PLoS Negl Trop Dis.  Nov 20;9(11):e0004233.

Bain O, Mutafchiev Y, Junker K, Guerrero R, Martin C, Lefoulon E, Uni S. 2015. Review of the genus Mansonella Faust, 1929 sensu lato (Nematoda: Onchocercidae), with descriptions of a new subgenus and a new subspecies. Zootaxa. Feb 11;3918(2):151-93.


Lefoulon E, Kuzmin Y, Plantard O, Mutafchiev Y, Otranto D, Martin C, Bain O. 2014. Redescription of Cercopithifilaria rugosicauda (Böhm & Supperer, 1953) (Spirurida: Onchocercidae) of roe deer, with an emended diagnosis of the genus Cercopithifilaria and a genetic characterisation. Parasitol Int. Aug 7;63(6):808-816.

Armstrong SD, Babayan SA, Lhermitte-Vallarino N, Gray N, Xia D, Martin C, Kumar S, Taylor DW, Blaxter ML, Wastling JM, Makepeace BL. 2014. Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) reveals Maximal Diversity in Gravid Female Parasites. Mol Cell Proteomics. Jun 23. pii: mcp.M114.038539.

Karadjian G, Berrebi D, Dogna N, Vallarino-Lhermitte N, Bain O, Landau I, Martin C. 2014. Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice. Parasite. 21:16.

Arndts K, Specht S, Debrah AY, Tamarozzi F, Klarmann U, Mand S, Batsa L, Kwarteng A, Taylor M, Adjei O, Martin C, Layland LE, Hoerauf A. 2014. Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels. PLoS Negl Trop Dis. Feb 20;8(2):e2679.

Martin C. 2014. Odile Bain (april 28, 1939-october 16, 2012): a life dedicated to systematics and biology of filariae. PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2565.


Martin C. 2013. Obituary: Odile Bain. Parasite. 2013;20:22.

Nieguitsila A, Frutos R, Moulia C, Lhermitte-Vallarino N, Bain O, Gavotte L, Martin C. 2013. Fitness cost of Litomosoides sigmodontis filarial infection in mite vectors; implications of infected haematophagous arthropod excretory products in host-vector interactions. Biomed Res Int :584105.

Otranto D, Varcasia A, Solinas C, Scala A, Brianti E, Dantas-Torres F, Annoscia G, Martin C, Mutafchiev Y, Bain O. 2013. Redescription of Cercopithifilaria bainae Almeida & Vicente, 1984 (Spirurida, Onchocercidae) from a dog in Sardinia, Italy. Parasit Vectors. 4;6(1):132.

Uni S, Bain O, Suzuki K, Agatsuma T, Harada M, Motokawa M, Martin C, Lefoulon E, Fukuda M, Takaoka H. 2013. Acanthocheilonema delicata n. sp. (Nematoda: Filarioidea) from Japanese badgers (Meles anakuma): description, molecular identification, and Wolbachia screening. Parasitol Int. 62(1):14-23.

Bouchery T, Lefoulon E, Karadjian G, Nieguitsila A, Martin C. 2013. The symbiotic role of Wolbachia in Onchocercidae and its impact on filariasis. Clin Microbiol Infect. 19(2):131-40.


Makepeace BL, Martin C, Turner JD, Specht S. 2012. Granulocytes in helminth infection -- who is calling the shots? Curr Med Chem. 19(10):1567-86.

Bouchery T, Ehrhardt K, Lefoulon E, Hoffmann W, Bain O, Martin C. 2012. Differential tissular distribution of Litomosoides sigmodontis microfilariae between microfilaremic and amicrofilaremic mice following experimental infection. Parasite. 19(4):351-8.

Fall EH, Diagne M, Martin C, Mutafchiev Y, Granjon L, Ba K, Junker K, Bain O. 2012. Trichosomoides nasalis (Nematoda: Trichinelloidea) in the murid host Arvicanthis niloticus: migration to the epithelium of the nasal mucosa after intramuscular development. Parasite. 19(4):359-65.

Lefoulon E, Gavotte L, Junker K, Barbuto M, Uni S, Landmann F, Laaksonen S, Saari S, Nikander S, de Souza Lima S, Casiraghi M, Bain O, Martin C. 2012. A new type F Wolbachia from Splendidofilariinae (Onchocercidae) supports the recent emergence of this supergroup. Int J Parasitol. 42(11):1025-36.

Landmann F, Bain O, Martin C, Uni S, Taylor MJ, Sullivan W. Both asymmetric mitotic segregation and cell-to-cell invasion are required for stable germline transmission of Wolbachia in filarial nematodes. Biol Open. 1(6):536-47.

Bouchery T, Dénécé G, Attout T, Ehrhardt K, Lhermitte-Vallarino N, Hachet-Haas M, Galzi JL, Brotin E, Bachelerie F, Gavotte L, Moulia C, Bain O, Martin C. 2012. The chemokine CXCL12 is essential for the clearance of the filaria Litomosoides sigmodontis in resistant mice. PLoS One. 7(4):e34971.

Ziewer S, Hübner MP, Dubben B, Hoffmann WH, Bain O, Martin C, Hoerauf A, Specht S. 2012. Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis. PLoS Negl Trop Dis. 6(3):e1558.


Guerrero R, Bain O, Martin C, Barbuto M. 2011. A new species of Litomosoides (Nematoda: Onchocercidae), parasite of Nectomys palmipes (Rodentia: Cricetidae: Sigmodontinae) from Venezuela: description, molecular evidence, Wolbachia pipientis screening. Folia Parasitol (Praha). 58(2):149-56.

Ferri E, Bain O, Barbuto M, Martin C, Lo N, Uni S, Landmann F, Baccei SG, Guerrero R, de Souza Lima S, Bandi C, Wanji S, Diagne M, Casiraghi M. 2011. New insights into the evolution of Wolbachia infections in filarial nematodes inferred from a large range of screened species. PLoS One. 6(6):e20843.

Specht S, Frank JK, Alferink J, Dubben B, Layland LE, Denece G, Bain O, Förster I, Kirschning CJ, Martin C, Hoerauf A. 2011. CCL17 controls mast cells for the defense against filarial larval entry. J Immunol. 186(8):4845-52.

Hansen RD, Trees AJ, Bah GS, Hetzel U, Martin C, Bain O, Tanya VN, Makepeace BL. 2011. A worm's best friend: recruitment of neutrophils by Wolbachia confounds eosinophil degranulation against the filarial nematode Onchocerca ochengi. Proc Biol Sci. 278(1716):2293-302.


Martin C, Gavotte L. 2010. The bacteria Wolbachia in filariae, a biological Russian dolls' system: new trends in antifilarial treatments. Parasite. 17(2):79-89.


Attout T, Hoerauf A, Dénécé G, Debrah AY, Marfo-Debrekyei Y, Boussinesq M, Wanji S, Martinez V, Mand S, Adjei O, Bain O, Specht S, Martin C*. 2009. Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule. PLoS One. 4(12):e8234.

Junker K, Barbuto M, Casiraghi M, Martin C, Uni S, Boomker J, Bain O. 2009. Litomosa chiropterorum Ortlepp, 1932 (Nematoda: Filarioidea) from a South African miniopterid: redescription, Wolbachia screening and phylogenetic relationships with Litomosoides. Parasite. 16(1):43-50.

Ferri E, Barbuto M, Bain O, Galimberti A, Uni S, Guerrero R, Ferté H, Bandi C, Martin C, Casiraghi M. 2009. Integrated taxonomy: traditional approach and DNA barcoding for the identification of filarioid worms and related parasites (Nematoda). Front Zool. 7;6:1.


Attout T, Martin C, Babayan SA, Kozek WJ, Bazzocchi C, Oudet F, Gallagher IJ, Specht S, Bain O. 2008. Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain. Parasitol Int. 57(2):201-11.

Burdon PC, Martin C, Rankin SM. 2008. Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines. Br J Haematol. 142(1):100-8.

Bain O, Casiraghi M, Martin C, Uni S. 2008. The nematoda Filarioidea: critical analysis linking molecular and traditional approaches. Parasite. 15(3):342-8.


Foubert P, Silvestre JS, Souttou B, Barateau V, Martin C, Ebrahimian TG, Leré-Déan C, Contreres JO, Sulpice E, Levy BI, Plouët J, Tobelem G, Le Ricousse-Roussanne S. 2007. PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells. J Clin Invest. 117(6):1527-37.


Guerrero R, Bain O, Attout T, Martin C. 2006. The infective larva of Litomosoides yutajensis Guerrero et al., 2003 (Nematoda: Onchocercidae), a Wolbachia-free filaria from bat. Parasite. 13(2):127-30.

Martin C, Bain O, Jouvenet N, Raharimanga V, Robert V, Rousset D. 2006. First report of Litomosa spp. (Nematoda: Filarioidea) from Malagasy bats; review of the genus and relationships between species. Parasite. 13(1):3-10.

Martin C, Bridger GJ, Rankin SM. 2006. Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro. Br J Haematol. 134(3):326-9.


Attout T, Babayan S, Hoerauf A, Taylor DW, Kozek WJ, Martin C, Bain O. 2005. Blood-feeding in the young adult filarial worms Litomosoides sigmodontis. Parasitology. 130(Pt 4):421-8.

Babayan S, Attout T, Specht S, Hoerauf A, Snounou G, Rénia L, Korenaga M, Bain O, Martin C. 2005. Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis. Med Microbiol Immunol. 194(3):151-62.

Martin C, Burdon PC, Rankin SM. 2005. The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner. Blood. 105(6):2543-8.


Casiraghi M, Bain O, Guerrero R, Martin C, Pocacqua V, Gardner SL, Franceschi A, Bandi C. 2004. Mapping the presence of Wolbachia pipientis on the phylogeny of filarial nematodes: evidence for symbiont loss during evolution. Int J Parasitol. 34(2):191-203.

Bain O, Attout T, Babayan S, Kozek W, Martin C. 2004. Biology of filariae in the vertebrate host: Litomosoides sigmodontis casts light on several “grey areas. Editorial Medimond-International Proceedings Monduzzi Editore.


Martin C, Burdon PC, Bridger G, Gutierrez-Ramos JC, Williams TJ, Rankin SM. 2003. Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. Immunity. 19(4):583-93.

Babayan S, Ungeheuer MN, Martin C, Attout T, Belnoue E, Snounou G, Rénia L, Korenaga M, Bain O. 2003. Resistance and susceptibility to filarial infection with Litomosoides sigmodontis are associated with early differences in parasite development and in localized immune reactions. Infect Immun. 71(12):6820-9.

Guerrero R, Martin C, Bain O. 2003. Litomosoides yutajensis n. sp., first record of this filarial genus in a mormoopid bat. Parasite. 10(3):219-25.


Guerrero R, Martin C, Gardner SL, Bain O. 2002.New and known species of Litomosoides (Nematoda : Filarioidea): Important adult and larval characters and taxonomic changes. Comp. Parasitol. 69(2):177-195.


Paperna I, Martin C. 2001.The development and fine structure of Lankesterella cf. dicroglossi (Apicomplexa: Lankesterellidae) infecting frogs in Niger, West Africa. Folia Parasitol (Praha). 48(3):178-86.

Martin C, Saeftel M, Vuong PN, Babayan S, Fischer K, Bain O, Hoerauf A. 2001.B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection. Infect Immun. 69(11):7067-73.


Martin C, Al-Qaoud KM, Ungeheuer MN, Paehle K, Vuong PN, Bain O, Fleischer B, Hoerauf A. 2000. IL-5 is essential for vaccine-induced protection and for resolution of primary infection in murine filariasis. Med Microbiol Immunol. 189(2):67-74.

Martin C, Le Goff L, Ungeheuer MN, Vuong PN, Bain O. 2000. Drastic reduction of a filarial infection in eosinophilic interleukin-5 transgenic mice. Infect Immun. 68(6):3651-6.

Le Goff L, Martin C, Oswald IP, Vuong PN, Petit G, Ungeheuer MN, Bain O. 2000. Parasitology and immunology of mice vaccinated with irradiated Litomosoides sigmodontis larvae. Parasitology. 120:271-80.


  • Master 2 Parasitologie-Mycologie, Université Paris VI
  • Master 2 Infectiologie, Université Tours
  • Master 1 Biodiversité et interactions microbiennes et parasitaires, Montpellier
  • Professional training, SULIM, Université Limoges

Main collaborations

  • Dr Marc Huebner & Prof Achim Hoerauf - IMMIP, University Hospital Bonn - Germany
  • Dr Leo Carlin - Imperial College London - UK
  • Dr Laurent Gavotte & Prof Catherine Moulia - ISEM, Université de Montpellier – France
  • Dr Frederic Landmann - CRBM CNRS UMR5237 Montpellier - France
  • Dr Ben Makepeace - University of Liverpool - UK
  • Prof Domenico Otranto – University of Bari - Italia
  • Dr Ivan Scandale- DNDi - Genève –Suisse
  • Dr Daniel Kulke - BAYER-Germany
  • Dr Ricardo Guerrero - University of Caracas - Venezuela
  • Dr Moustapha Diagne - Université de Dakar - Sénégal
  • Dr Kerstin Junker - ARC OVI - South Africa
  • Dr Shigehiko Uni - Osaka City University Medical School - Japan

Current members of the group

  • Dr Nathaly Vallarino Lhermitte: CDD
  • Josephine Gal: PhD student
  • Jules Rodrigues: PhD student
  • Clément Cormerais: PhD student
  • Frédéric fercoq: Postdoc

Former members of the group

  • Tarik Attout : Postdoc
  • Adelaïde Nieguitsila: Postdoc
  • Nicolas Pionnier: Postdoc
  • Gaëlle Dénécé: PhD student
  • Tiffany Bouchery: PhD student
  • Gregory Karadjian: PhD student
  • Emilie Lefoulon: PhD student
  • Frédéric Fercoq: PhD student
  • Estelle Rémion: PhD student
  • Jessica Renshaw : BSc ERASMUS