Entité de rattachement
PPL Parasites et Protistes Libres
Spécialité
Interactions hôte-parasite, Nématodes, Filaires, Wolbachia, Immunologie, Biologie moléculaire et cellulaire

Contact

Réseaux sociaux
Courriel
cmartin [at] mnhn.fr
Téléphone
+33 1 40 79 34 96
Adresse(s)

61 rue Buffon (CP52)

75005 Paris

Responsabilités dans l'unité

Responsable de l'équipe PPL (Parasites et Protistes Libres)

Responsabilités hors unité

Membre élu au conseil de département  AVIV du MNHN (depuis 2017)

Membre du conseil scientifique du DIM “One Health” (depuis 2017)

Membre du comité ANR CES 18 Innovation Biomédicale (depuis 2020)

Membre du comité scientifique du programme MNHN "ATM Blanches" (2016-2018)

Coordinatrice du programme MNHN "ATM Microorganismes" (2014-2015)

Présidente de la Société Française de Parasitologie (2018-2020)

Collections

Présentation

Emplois et formations

  • Professeur MNHN [2021-...]
  • CR1 INSERM [2005 - 2021]
  • HDR : Université de Paris VI, France [2007]
  • Institut des Vaisseaux et du Sang (IVS), Hopital Lariboisière, Paris , France [2004 - 2005]
  • Wellcome Trust Postdoctoral Research Associate Imperial College, London, UK [2001-2004]
  • PhD : Université de Paris VI, France [2001]

Activités de recherche

Mon domaine d'expertise concerne les filaires (nématodes Onchocercidae, parasites de vertébrés), et leur endosymbionte Wolbachia. Plusieurs espèces sont des agents de graves maladies tropicales, comme les filarioses lymphatiques, l'onchocercose («cécité de rivières») et la loase.

Une autre particularité intéressante des filaires est qu'elles peuvent héberger une bactérie endosymbionte Wolbachia, présente aussi chez les arthropodes. Cette bactérie est actuellement une cible thérapeutique car les filaires ne survivent pas sans elle.

Nous nous intéressons à cette association symbiotique tripartite: un microorganisme eucaryote – Onchocercidae–, une bactérie endosymbionte – Wolbachia – et un organisme évolué –un vertébré terrestre– et aux processus d'adaptation au niveau moléculaire et cellulaire de ces partenaires les uns aux autres. Plus spécifiquement nous étudions:

1 - les relations phylogénétiques entre filaires et bactéries

2 - les migrations et le développement des filaires et leurs interactions avec l'environnement cellulaire (granulocytes, macrophages) et tissulaire (lymphatique, sanguin et pulmonaire) de leur hôte vertébré

3 - les réponses immunitaires du vertébré spécifiques de la bactérie et celles spécifiques de la filaire, et leurs modifications par des agents de stress, tels que des processus de vaccination, adjuvants ou des traitements anti-filariens/anti-bactériens.

Nous avons développé un modèle murin de filariose (Litomosoides sigmodontis ) que nous utilisons pour les points 2 et 3.

Actuellement nous nous intéressons à l'histoire évolutive des filaires d'oiseaux  et la coévolution entre collemboles et Wolbachia (collab. C. d'Haesse, UMR7179),  et nous étudions l'inflammation pulmonaire chronique dans le modèle de filariose avec L. sigmodontis.

 

Queue et spicules d'une filaire adulte mâle L. sigmodontis âgé de 60 jours © Landmann et Martin

Queue et spicules d'une filaire adulte mâle L. sigmodontis âgé de 60 jours © Landmann et Martin

Crédits
© Landmann et Martin

 

Topologie de Wolbachia © MNHN

Topologie de Wolbachia, une bactérie endosymbionte des filaires er des arthropodes (adaptée de Lefoulon et al. (2016), PeerJ 4:e1840)

Publications

ORCID:   https://orcid.org/0000-0003-3801-2595

2022

Remion E, Gal J, Chaouch S, Rodrigues J, Lhermitte-Vallarino N, Alonso J, Kohl L, Hübner MP, Fercoq F, Martin C. Unbalanced Arginine pathway and altered maturation of pleural macrophages in Th2-deficient mice during Litomosoides sigmodontis filarial infection. Front Immunol. 2022 Oct 24;13:866373. doi: 10.3389/fimmu.2022.866373. eCollection 2022. PMID: 36353644.

Hawryluk N, Robinson D, Shen Y, Kyne G, Bedore M, Menon S, Canan S, von Geldern T, Townson S, Gokool S, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Dalvie D, Specht S, Hübner MP, Scandale I. Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections. J Med Chem. 2022 Aug 25;65(16):11388-11403. doi: 10.1021/acs.jmedchem.2c00960. Epub 2022 Aug 16. PMID: 35972896

Okazaki D, Fukuda M, Hebisawa A, Uni S, Junker K, Suzuki Y, Nakano M, Agatsuma T, Hasegawa H, Yamada M, Nakatani J, Hara T, Martin C, Kimura D, Takaoka H. Zoonotic infection caused by Onchocerca japonica (Nematoda: Filarioidea) in a 69-year-old woman in Kanto Region, Eastern Honshu, Japan
Parasitol Int. 2022 Dec;91:102643. doi: 10.1016/j.parint.2022.102643. Epub 2022 Aug 9. PMID: 35961578
 
Hawryluk N, Zhiru L, Carlow C, Gokool S, Townson S, Kreiss T, Chojnowski A, Prorok M, Siekierka J, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Canan S, Khetani V, Zeldis J, Specht S, Hübner MP, Scandale I. Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization. Int J Parasitol Drugs Drug Resist. 2022 Aug;19:89-97. doi: 10.1016/j.ijpddr.2022.06.002. Epub 2022 Jun 23.

S. Uni, A. SyihanMat Udin, P. EanTan, J. Rodrigues, C. Martin, K. Junker, T. Agatsuma, V. Lun Low, Y. Ai-Lian Lim, W. Saijuntha, H. Omar, N. Afiquah Zainuri, M. Fukuda, D. Kimura, M. Matsubayashi, S. Uga, H. Takaoka, M. Sofian Azirun, R. Ramli. Description and molecular characterisation of Pelecitus copsychi Uni, Mat Udin & Martin n. sp. (Nematoda: Onchocercidae) from the white-rumped shama Copsychus malabaricus (Scopoli) (Passeriformes: Muscicapidae) of Pahang, Malaysia. Current Research in Parasitology & Vector-Borne Diseases, Volume 2, 2022, 100078. https://doi.org/10.1016/j.crpvbd.2022.100078

2021

Ehrens A, Lenz B, Neumann AL, Giarrizzo S, Reichwald JJ, Frohberger SJ, Stamminger W, Buerfent BC, Fercoq F, Martin C, Kulke D, Hoerauf A, Hübner MP. Microfilariae Trigger Eosinophil Extracellular DNA Traps in a Dectin-1-Dependent Manner. Cell Rep. 2021 Jan 12;34(2):108621. doi: 10.1016/j.celrep.2020.108621.

Borba VH, Martin C, Machado-Silva JR, Xavier SCC, de Mello FL, Iñiguez AM. Machine learning approach to support taxonomic species discrimination based on helminth collections data. Parasit Vectors. 2021 May 1;14(1):230.  doi: 10.1186/s13071-021-04721-6.

 

2020

Card C, Wilson DS, Hirosue S, Rincon-Restrepo M, de Titta A, Güç E, Martin C, Bain O, Swartz MA, Kilarski WW.  Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers. Sci Rep. 2020 Jan 23;10(1):1055. doi: 10.1038/s41598-020-57995-8.

Fercoq F, Remion E, Vallarino-Lhermitte N, Alonso J, Raveendran L, Nixon C, Le Quesne J, Carlin LM, Martin C. Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents. Parasit Vectors. 2020 Nov 7;13(1):551. doi: 10.1186/s13071-020-04428-0.

Frohberger SJ, Fercoq F, Neumann AL, Surendar J, Stamminger W, Ehrens A, Karunakaran I, Remion E, Vogl T, Hoerauf A, Martin C, Hübner MP.  S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis. PLoS Negl Trop Dis 2020 14(2): e0008119. https://doi.org/10.1371/journal.pntd.0008119

Gaillard CM, Pion SD, Hamou H, Sirima C, Bizet C, Lemarcis T, Rodrigues J, Esteban A, Peeters M, Mpoudi Ngole E, Mombo I, Liégeois F, Martin C, Boussinesq M, Locatelli S. Detection of DNA of filariae closely related to Mansonella perstans in faecal samples from wild non-human primates from Cameroon and Gabon. Parasit Vectors. 2020 Jun 16;13(1):313. doi: 10.1186/s13071-020-04184-1.

Hennocq Q, Helary A, Debelmas A, Monsel G, Labat A, Bertolus C, Martin C, Caumes E. Oral migration of Dirofilaria repens after creeping dermatitis. Parasite. 2020; 27:16. doi: 10.1051/parasite/2020015. Epub 2020 Mar 18.

Hübner MP, Martin C, Specht S, Koschel M, Dubben B, Frohberger SJ, Ehrens A, Fendler M, Struever D, Mitre E, Vallarino-Lhermitte N, Gokool S, Lustigman S, Schneider M, Townson S, Hoerauf A, Scandale I. Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro. PLoS Negl Trop Dis. 2020 Jul 6;14(7):e0008427. doi: 10.1371/journal.pntd.0008427. eCollection 2020 Jul.

Lefoulon E, Clark T, Guerrero R, Cañizales I, Cardenas-Callirgos JM, Junker K, Vallarino-Lhermitte N, Makepeace BL, Darby AC, Foster JM, Martin C, Slatko BE. Diminutive, degraded but dissimilar: Wolbachia genomes from filarial nematodes do not conform to a single paradigm. Microb Genom. 2020 Dec 9. doi: 10.1099/mgen.0.000487.

Uni S, Mat Udin AS, Agatsuma T, Junker K, Saijuntha W, Bunchom N, Fukuda M, Martin C, Lefoulon E, Labat A, Khan FAA, Low VL, Cheah PL, Lim YA, Ramli R, Belabut DM, Zainuri NA, Matsubayashi M, Omar H, Bhassu S, Uga S, Hashim R, Takaoka H, Azirun MS. Description, molecular characteristics and Wolbachia endosymbionts of Onchocerca borneensis Uni, Mat Udin & Takaoka n. sp. (Nematoda: Filarioidea) from the Bornean bearded pig Sus barbatus Müller (Cetartiodactyla: Suidae) of Sarawak, Malaysia. Parasit Vectors. 2020 Feb 6;13(1):50. doi: 10.1186/s13071-020-3907-8.

 

2019

Quintana JF, Kumar S, Ivens A, Chow FWN, Hoy AM, Fulton A, Dickinson P, Martin C, Taylor M, Babayan SA, Buck AH. Comparative analysis of small RNAs released by the filarial nematode Litomosoides sigmodontis in vitro and in vivo. PLoS Negl Trop Dis. 2019 Nov 26;13(11):e0007811. doi: 10.1371/journal.pntd.0007811. eCollection 2019 Nov.

Regnier A, Martin C, Semin MO, Lienard E, Geffre A, Douet JY, Raymond-Letron I. (2019) Subconjunctival nodule due to Setaria equina erratic migration in a horse: First case report. Vet Ophthalmol. 2019 Nov;22(6):921-927. doi: 10.1111/vop.12675. Epub 2019 May 2.

Fercoq F, Remion E, Frohberger SJ, Vallarino-Lhermitte N, Hoerauf A, Le Quesne J, Landmann F, Hübner MP, Carlin LM, Martin C. IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation. PLoS Negl Trop Dis. 2019 Aug 30;13(8):e0007691. doi: 10.1371/journal.pntd.0007691. eCollection 2019 Aug.

Mirzaei M, Ghahvei Y, Lefoulon E, Lia RP, Otranto D, Martin C, Sazmand A. (2019) Morphological and molecular characterization of Onchocerca fasciata (Nematoda, Onchocercidae) from dromedary camels (Camelus dromedarius) in Iran. Parasite. 2018;25:50. doi: 10.1051/parasite/2018045. Epub 2018 Sep 20.

Kilarski WW, Martin C, Pisano M, Bain O, Babayan SA, Swartz MA. Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels. Nat Commun. 2019 Jul 1;10(1):2895. doi: 10.1038/s41467-019-10675-2.

2018

Latrofa MS, Annoscia G, Colella V, Cavalera MA, Maia C, Martin C, Šlapeta J, Otranto D. A real-time PCR tool for the surveillance of zoonotic Onchocerca lupi in dogs, cats and potential vectors. PLoS Negl Trop Dis. 2018 Apr 4;12(4):e0006402. doi: 10.1371/journal.pntd.0006402. eCollection 2018 Apr.

Colella V, Maia C, Pereira A, Gonçalves N, Caruso M, Martin C, Cardoso L, Campino L, Scandale I, Otranto D.  Evaluation of oxfendazole in the treatment of zoonotic Onchocerca lupi infection in dogs. PLoS Negl Trop Dis. Jan 29;12(1):e0006218. doi: 10.1371/journal.pntd.0006218. eCollection 2018 Jan.

Specht S, Pfarr KM, Arriens S, Hübner MP, Klarmann-Schulz U, Koschel M, Sternberg S, Martin C, Ford L, Taylor MJ, Hoerauf A.  Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model. PLoS Negl Trop Dis. 2018 Jan 4;12(1):e0006116. doi: 10.1371/journal.pntd.0006116. eCollection 2018 Jan .

2017

Karadjian G, Fercoq F, Pionnier N, Vallarino-Lhermitte N, Lefoulon E, Nieguitsila A, Specht S, Carlin LM, Martin C.  Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. PLoS Negl Trop Dis. 2017 May 9;11(5):e0005596.

Uni S, Mat Udin AS, Agatsuma T, Saijuntha W, Junker K, Ramli R, Omar H, Lim YA, Sivanandam S, Lefoulon E, Martin C, Belabut DM, Kasim S, Abdullah Halim MR, Zainuri NA, Bhassu S, Fukuda M, Matsubayashi M, Harada M, Low VL, Chen CD, Suganuma N, Hashim R, Takaoka H, Azirun MS. Morphological and molecular characteristics of Malayfilaria sofiani Uni, Mat Udin & Takaoka n. g., n. sp. (Nematoda: Filarioidea) from the common treeshrew Tupaia glis Diard & Duvaucel (Mammalia: Scandentia) in Peninsular Malaysia. Parasit Vectors. 2017. Apr 20;10(1):194.

Lefoulon E, Giannelli A, Makepeace BL, Mutafchiev Y, Townson S, Uni S, Verocai GG, Otranto D, Martin CWhence river blindness? The domestication of mammals and host-parasite co-evolution in the nematode genus Onchocerca. Int J Parasitol. 2017 Jul;47(8):457-470. doi: 10.1016/j.ijpara.2016.12.009.

Lia RP, Mutafchiev Y, Veneziano V, Giannelli A, Abramo F, Santoro M, Latrofa MS, Cantacessi C, Martin C, Otranto D, Bertuglia A, Riccio B. Filarial infection caused by Onchocerca boehmi (Supperer, 1953) in a horse from Italy. Parasitol Res. 2017 Jan;116(1):191-198.

2016

Pionnier N, Brotin E, Karadjian G, Hemon P, Gaudin-Nomé F, Vallarino-Lhermitte N, Nieguitsila A, Fercoq F, Aknin ML, Marin-Esteban V, Chollet-Martin S, Schlecht-Louf G, Bachelerie F, Martin C. Neutropenic mice provide insight into the role of skin-Infiltrating Neutrophils in the host protective Immunity against Filarial Infective Larvae. PLoS Negl Trop Dis. 2016.Apr 25;10(4):e0004605

Lefoulon E, Bain O, Makepeace BL, d'Haese C, Uni S, Martin C, Gavotte L. 2016. Breakdown of coevolution between symbiotic bacteria Wolbachia and their filarial hosts. PeerJ. Mar 28;4:e1840.

2015

Lefoulon E, Bain O, Bourret J, Junker K, Guerrero R, Cañizales I, Kuzmin Y, Satoto TB, Cardenas-Callirgos JM, de Souza Lima S, Raccurt C, Mutafchiev Y, Gavotte L, Martin C. Shaking the Tree: Multi-locus Sequence Typing Usurps Current Onchocercid (Filarial Nematode) Phylogeny. PLoS Negl Trop Dis.  2015. Nov 20;9(11):e0004233.

Bain O, Mutafchiev Y, Junker K, Guerrero R, Martin C, Lefoulon E, Uni S. Review of the genus Mansonella Faust, 1929 sensu lato (Nematoda: Onchocercidae), with descriptions of a new subgenus and a new subspecies. Zootaxa. 2015. Feb 11;3918(2):151-93.

2014

Lefoulon E, Kuzmin Y, Plantard O, Mutafchiev Y, Otranto D, Martin C, Bain O. Redescription of Cercopithifilaria rugosicauda (Böhm & Supperer, 1953) (Spirurida: Onchocercidae) of roe deer, with an emended diagnosis of the genus Cercopithifilaria and a genetic characterisation. Parasitol Int. Aug 2014. 7;63(6):808-816.

Armstrong SD, Babayan SA, Lhermitte-Vallarino N, Gray N, Xia D, Martin C, Kumar S, Taylor DW, Blaxter ML, Wastling JM, Makepeace BL. Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) reveals Maximal Diversity in Gravid Female Parasites. Mol Cell Proteomics. 2014. Jun 23. pii: mcp.M114.038539.

Karadjian G, Berrebi D, Dogna N, Vallarino-Lhermitte N, Bain O, Landau I, Martin CCo-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice. Parasite. 2014. 21:16.

Arndts K, Specht S, Debrah AY, Tamarozzi F, Klarmann U, Mand S, Batsa L, Kwarteng A, Taylor M, Adjei O, Martin C, Layland LE, Hoerauf A. Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels. PLoS Negl Trop Dis. 2014. Feb 20;8(2):e2679.

Martin C. 2014. Odile Bain (april 28, 1939-october 16, 2012): a life dedicated to systematics and biology of filariae. PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2565.

2013

Martin C. 2013. Obituary: Odile Bain. Parasite. 2013;20:22.

Nieguitsila A, Frutos R, Moulia C, Lhermitte-Vallarino N, Bain O, Gavotte L, Martin C. 2013. Fitness cost of Litomosoides sigmodontis filarial infection in mite vectors; implications of infected haematophagous arthropod excretory products in host-vector interactions. Biomed Res Int :584105.

Otranto D, Varcasia A, Solinas C, Scala A, Brianti E, Dantas-Torres F, Annoscia G, Martin C, Mutafchiev Y, Bain O. 2013. Redescription of Cercopithifilaria bainae Almeida & Vicente, 1984 (Spirurida, Onchocercidae) from a dog in Sardinia, Italy. Parasit Vectors. 4;6(1):132.

Uni S, Bain O, Suzuki K, Agatsuma T, Harada M, Motokawa M, Martin C, Lefoulon E, Fukuda M, Takaoka H. 2013. Acanthocheilonema delicata n. sp. (Nematoda: Filarioidea) from Japanese badgers (Meles anakuma): description, molecular identification, and Wolbachia screening. Parasitol Int. 62(1):14-23.

Bouchery T, Lefoulon E, Karadjian G, Nieguitsila A, Martin C. 2013. The symbiotic role of Wolbachia in Onchocercidae and its impact on filariasis. Clin Microbiol Infect. 19(2):131-40.

2012

Makepeace BL, Martin C, Turner JD, Specht S. 2012. Granulocytes in helminth infection -- who is calling the shots? Curr Med Chem. 19(10):1567-86.

Bouchery T, Ehrhardt K, Lefoulon E, Hoffmann W, Bain O, Martin C. 2012. Differential tissular distribution of Litomosoides sigmodontis microfilariae between microfilaremic and amicrofilaremic mice following experimental infection. Parasite. 19(4):351-8.

Fall EH, Diagne M, Martin C, Mutafchiev Y, Granjon L, Ba K, Junker K, Bain O. 2012. Trichosomoides nasalis (Nematoda: Trichinelloidea) in the murid host Arvicanthis niloticus: migration to the epithelium of the nasal mucosa after intramuscular development. Parasite. 19(4):359-65.

Lefoulon E, Gavotte L, Junker K, Barbuto M, Uni S, Landmann F, Laaksonen S, Saari S, Nikander S, de Souza Lima S, Casiraghi M, Bain O, Martin C. 2012. A new type F Wolbachia from Splendidofilariinae (Onchocercidae) supports the recent emergence of this supergroup. Int J Parasitol. 42(11):1025-36.

Landmann F, Bain O, Martin C, Uni S, Taylor MJ, Sullivan W. Both asymmetric mitotic segregation and cell-to-cell invasion are required for stable germline transmission of Wolbachia in filarial nematodes. Biol Open. 1(6):536-47.

Bouchery T, Dénécé G, Attout T, Ehrhardt K, Lhermitte-Vallarino N, Hachet-Haas M, Galzi JL, Brotin E, Bachelerie F, Gavotte L, Moulia C, Bain O, Martin C. 2012. The chemokine CXCL12 is essential for the clearance of the filaria Litomosoides sigmodontis in resistant mice. PLoS One. 7(4):e34971.

Ziewer S, Hübner MP, Dubben B, Hoffmann WH, Bain O, Martin C, Hoerauf A, Specht S. 2012. Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis. PLoS Negl Trop Dis. 6(3):e1558.

 

Principales collaborations

 

  • Dr Marc Huebner & Prof Achim Hoerauf - IMMIP, University Hospital Bonn - Germany 
  • Dr Laurent Gavotte & Prof Catherine Moulia - ISEM, Université de Montpellier – France
  • Dr Frederic Landmann - CRBM CNRS UMR5237 Montpellier - France
  • Prof Erika Martins Braga - Universidade Federal de Minas Gerais - Brésil
  • Dr Ivan Scandale & Dr Sabine Specht - DNDi - Genève –Suisse 
  • Dr Ben Makepeace - University of Liverpool - UK
  • Dr Shigehiko Uni - Osaka City University Medical School - Japan
  • Prof Domenico Otranto – University of Bari - Italia
  • Dr Leo Carlin - Beatson Institute - UK
  • Dr Ricardo Guerrero - University of Caracas - Venezuela

Membres actuels du groupe

  • Dr Linda Kohl, MC MNHN
  • Dr Nathaly Vallarino Lhermitte: CDD
  • Dr Frédéric Fercoq: Postdoc
  • Clément Cormerais: doctorant
  • Jules Rodrigues: doctorant
  • Josephine Gal: doctorante

Membres passés du groupe

  • Tarik Attout : postdoctorant
  • Adelaïde Nieguitsila: postdoctorante
  • Nicolas Pionnier: postdoctorant
  • Gaëlle Dénécé: doctorante ED, UPMC
  • Tiffany Bouchery: doctorante ED, UPMC
  • Fréderic Fercoq: doctorant ED227, MNHN
  • Gregory Karadjian: doctorant ED227, MNHN
  • Emilie Lefoulon: doctorante ED227, MNHN
  • Estelle Rémion: doctorante ED227, MNHN