Angélique Salandre

Research activities

    Bacteriocins are antimicrobial peptides produced by bacteria via the ribosomal biosynthesis pathway. They can undergo various post-translational modifications, providing a wide range of structures. These peptides play a major role in microbial competition, particularly within the gut microbiota. Bacteriocins are a promising alternative to antibiotics because of the diversity and originality of their mechanisms of action and, in some cases, their targeted action on a pathogen.

    The thesis project is part of the AviBiocin project, which aims to examine the potential of enterobacterial bacteriocins (called microcins) as an alternative to antibiotics in poultry farming.

    The first objective will be to isolate and characterise the structure of a new microcin discovered by genome mining. The second objective will be to examine, for several microcines that are already known, whether these peptides can induce resistance or persistence to themselves or corss resistance/persistance to antibiotics.