Affiliation entity
BIM Biochemistry of Microbial Interactions
Interdisplinary research theme
Métabolomics, Toxicology, Analytical chemistry, Metabolism of xenobiotics and metabolic bioactivation, Systems biology and multidimensional statistics.
Speciality
Metabolomics and modeling of functional interactions of microorganisms and host in procaryote and eucaryote organisms.

Contact

E-mail
alain.paris [at] mnhn.fr
Phone
01 40 79 54 12
Address(es)

43 rue Buffon

24 allée des crapauds
75005 Paris

Teaching

  • French Museum of Natural History Master: “Evolution, natural heritage & society”
  • Master I: course : “Metabolomics: pratical aspects”
  • Master II: Orientation “Molecules and therapeutic target”, course: “Metabolomics for a renewed clinical approach”
  • Master II: Orientation “Microbiology, environment and health”, course: “Metabolomics used to characterize ecosystem”

Presentation

Research activities

Use of metabolomics to phenotype organisms for a characterisation of toxicological-origin disruptions or those in functional interaction with other organisms to model using statistics symbiosis, based on a longitudinal follow-up.

Collaborations:

  • 2014-: Dr. Estelle Rathahao-Paris (INRA) and Dr. Sandra Alves (Sorbonne University): Use of FT-MS to get a metabolomic phenotyping of urines collected on laboratory animals or subjects enrolled in dedicated cohorts. PhD thesis of Béninia Habchi (2014-2017).
  • 2016-: Dr. Céline Domange (AgroParisTech, Paris): Effect of saponins on ruminal metabolism in goat and metabolic variation in lactating and gestational periods. PhD thesis of Rafael Otaviano do Rego (Rio de Janeiro, Brazil)
  • 2015-: Dr. Isabelle Domart-Coulon and Dr. Marie-Lise Bourguet on metabolomic phenotyping of sponges and corals.
  • 2014-: Dr. Benjamin Marie and Dr. Benoît Sotton on metabolomic phenotyping of fish exposed to cyanobacteria.

Expertise:

Feed toxicology at the national food safety agency (ANSES)

Publications

2022
  • Bekhti Nihel, Castelli Florence, Paris Alain, Guillon Blanche, Junot Christophe, Moiron Clémence, Fenaille François & Adel-Patient Karine, 2022 — The Human Meconium Metabolome and Its Evolution during the First Days of Life. Metabolites vol. 12, , p. 414
    ISSN
    2218-1989
    https://dx.doi.org/10.3390/metabo12050414
2021
  • Paris Alain, Labrador Boris, Lejeune François-Xavier, Canlet Cécile, Molina Jérôme, Guinot Michel, Mégret Armand, Rieu Michel, Thalabard Jean-Christophe & Le Bouc Yves, 2021 — Metabolomic signatures in elite cyclists: differential characterization of a seeming normal endocrine status regarding three serum hormones. Metabolomics vol. 17, , p. 67
    ISSN
    1573-3890
    https://dx.doi.org/10.1007/s11306-021-01812-4
  • Rathahao-Paris Estelle, Alves Sandra & Paris Alain, 2021 — « High-Throughput Metabolomics Using Flow Injection Analysis and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry » in Metabolomics.. vol. 159, , p. 9-23
    ISBN
    978-1-07-160864-7
    https://dx.doi.org/10.1007/978-1-0716-0864-72
2020
  • Alves Sandra, Paris Alain & Rathahao-Paris Estelle, 2020 — Mass spectrometry-based metabolomics for an in-depth questioning of human health. Advances in Clinical Chemistry vol. 99, , p. 147-191
    ISSN
    2162-9471
    https://dx.doi.org/10.1016/bs.acc.2020.02.009
  • Lefort Gaëlle, Servien Rémi, Quesnel Hélène, Billon Yvon, Canario Laurianne, Iannuccelli Nathalie, Canlet Cécile, Paris Alain, Vialaneix Nathalie & Liaubet Laurence, 2020 — The maturity in fetal pigs using a multi-fluid metabolomic approach. Scientific Reports vol. 10, , p. 19912
    ISSN
    2045-2322
    https://dx.doi.org/10.1038/s41598-020-76709-8
2019
  • Lefort Gaëlle, Liaubet Laurence, Canlet Cécile, Tardivel Patrick, Père Marie-Christine, Quesnel Hélène, Paris Alain, Iannuccelli Nathalie, Vialaneix Nathalie & Servien Rémi, 2019 — ASICS : an R package for a whole analysis workflow of 1D 1H NMR spectra. Bioinformatics vol. 35, , p. 4356-4363
    ISSN
    1367-4803
    https://dx.doi.org/10.1093/bioinformatics/btz248
  • Sotton Benoît, Paris Alain, Le Manach Séverine, Blond Alain, Duval Charlotte, Qiao Qin, Catherine Arnaud, Combes Audrey, Pichon Valérie, Bernard Cécile & Marie Benjamin, 2019 — Specificity of the metabolic signatures of fish from cyanobacteria rich lakes. Chemosphere vol. 226, , p. 183-191
    ISSN
    1879-1298
    https://dx.doi.org/10.1016/j.chemosphere.2019.03.115
  • Stojiljkovic Natali, Leroux Fanny, Bubanj Saša, Popot Marie-Agnès, Paris Alain, Tabet Jean-Claude & Junot Christophe, 2019 — Tracking main environmental factors masking a minor steroidal doping effect using metabolomic analysis of horse urine by liquid chromatography–high-resolution mass spectrometry. European Journal of Mass Spectrometry vol. 25, , p. 339-353
    ISSN
    1469-0667
    https://dx.doi.org/10.1177/1469066719839034
  • Tourneroche Anne, Lami Raphaël, Hubas Cédric, Blanchet Elodie, Vallet Marine, Escoubeyrou Karine, Paris Alain & Prado Soizic, 2019 — Bacterial–Fungal Interactions in the Kelp Endomicrobiota Drive Autoinducer-2 Quorum Sensing. Frontiers in Microbiology vol. 10, ,
    ISSN
    1664-302X
    https://www.frontiersin.org/articles/10.3389/fmicb.2019.01693
2018
  • Habchi Baninia, Alves Sandra, Jouan-Rimbaud Bouveresse Delphine, Appenzeller Brice, Paris Alain, Rutledge Douglas N. & Rathahao-Paris Estelle, 2018 — Potential of dynamically harmonized Fourier transform ion cyclotron resonance cell for high-throughput metabolomics fingerprinting: control of data quality. Analytical and Bioanalytical Chemistry vol. 410, n° 2, p. 483-490
    ISSN
    1618-2642, 1618-2650
    https://dx.doi.org/10.1007/s00216-017-0738-3
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