Les tutelles
CNRS-MNHN
Philippe BILLIALD
Entité de rattachement
CCE Cyanobactéries, cyanotoxines et environnement
Thème interdisciplinaire de recherche
Utilisation de méthodes d'ingénierie moléculaire et d'approche basée sur la modélisation pour concevoir, ingénierie, affinité et humaniser des anticorps
Recherches
Habilité(e) à diriger des recherches
Spécialité
Biochimie / Immunologie / Toxicologie
Contact
Téléphone
01 40 79 31 55
Adresse(s)
12 rue Buffon
75005 Paris
Enseignement(s)
- Université Paris-Sud : Biochimie, Faculté de Pharmacie et Première Année Commune aux Etudes de Santé (Médecine, Pharmacie, Odontologie, Maïeutique)
- Muséum : M2 parcours Toxines, microorganismes et Médiateurs chimiques dans les Ecosystèmes
Publications
2020
- Avril 2020 — Loxoscelism: Advances and Challenges in the Design of Antibody Fragments with Therapeutic Potential. Envenoming due to Loxosceles spider bites still remains a neglected disease of particular medical concern in the Americas. To... Toxins. Vol. 12, n° 4, p. 256. Number: 4 Publisher: Multidisciplinary Digital Publishing Institute.,
2019
- Octobre 2019 — Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion. Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and... PLOS ONE. Vol. 14, n° 10, e0223773.,ISSN:1932-6203
2016
- Août 2016 — Generation of recombinant antibody fragments with toxin-neutralizing potential in loxoscelism. Loxosceles spider bites often lead to serious envenomings and no definite therapy has yet been established. In such a context,... Immunology Letters. Vol. 176, Supplement C, p. 90-96.,ISSN:0165-2478
- Mai 2016 — Immunodetection of the “brown” spider ( Loxosceles intermedia ) dermonecrotoxin with an scFv-alkaline phosphatase fusion protein. Immunology Letters. Vol. 173, p. 1-6.,ISSN:01652478
- Février 2016 — A method to confer Protein L binding ability to any antibody fragment. mAbs. Vol. 8, n° 2, p. 379-388.,ISSN:1942-0862, 1942-0870
2014
- Août 2014 — Engineering Venom’s Toxin-Neutralizing Antibody Fragments and Its Therapeutic Potential. Toxins. Vol. 6, n° 8, p. 2541-2567.,ISSN:2072-6651
- Avril 2014 — Colorimetric engineered immunoprobe for the detection and quantification of microcystins. Journal of Immunological Methods. Vol. 406, p. 124-130.,ISSN:00221759
2013
- Juin 2013 — Creation of recombinant antigen-binding molecules derived from hybridomas secreting specific antibodies. This protocol describes the design and development of recombinant monovalent antigen-binding molecules derived from monoclonal... Nature Protocols. Vol. 8, n° 6, p. 1125-1148.,ISSN:1754-2189
2012
- Décembre 2012 — The future of glycoprotein VI as an antithrombotic target. Summary. The treatment of acute coronary syndromes has been considerably improved in recent years with the introduction of... Journal of Thrombosis and Haemostasis. Vol. 10, n° 12, p. 2418-2427.,ISSN:1538-7836
- Avril 2012 — Diabody Mixture Providing Full Protection against Experimental Scorpion Envenoming with Crude Androctonus australis Venom. Journal of Biological Chemistry. Vol. 287, n° 17, p. 14149-14156.,ISSN:0021-9258, 1083-351X