MCAM is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
Séverine ZIRAH
Séverine ZIRAH
Lecturer
Lecturer
Affiliated entity
BIM Biochemistry of Microbial Interactions
Interdisciplinary research theme
Spectroscopic methods (mass spectrometry, NMR), Biochemistry
Researches
Accreditation to supervise research
Contact
Social networks
E-mail
Phone
01 40 79 31 40
Address(es)
63 rue Buffon
75005 Paris
Responsibilities in the research group
- Coordinator (with Benjamin Marie) of the technical platforms of NMR and bio-organic mass spectrometry of the Museum
- Co-organization of the lab seminars
- elected member of MCAM committee
Teaching
- Co-responsible of the Master 2 program « Molecules and Therapeutic Targets», component of the Master «Molecular and Cellular Biology », Speciality « Biochemistry and Molecular Biology» of University Pierre & Marie Curie and of the Master « Evolution, Natural Patrimony and Societies », Speciality « Nature Mechanisms and Environment » of the National Museum of Natural History
- Co-responsible of teaching units: MVE6: Defence and Communication Molecules from Microorganisms, MVE21: Characterization, role and valorisation of microbial compounds, MVE30: Isolation and structural characterization of biomolecules, MVE36: Molecules and Therapeutic Targets.
- Courses and practical classes on spectroscopic methods (NMR, mass spectrometry) applied to the characterization of peptides. M2 (MVE21, MVE36)
- Courses on metabolomics and proteomics. M1 (4V131, UPMC) and M2 (MVE41)
- Courses on the diversity and role of microbial compounds (antibiotics, transport proteins, quorum sensing molecules,…). M1 (MVE5, MVE6)
- Courses on statistics introduction to R, univariate and multivariate statistics. M1 (TC3ini, TC3), M2 (SEP36) and doctorate school modules (R applications and R multivariate analysis).
- Courses and practical classes on smass spectrometry and RMN, Licence Pro "drug development", IUT Créteil.
Research activities
Ribosomally synthesized and post-translationally modified peptides (RiPPs) from bacteria: global and targeted spectroscopic methods to discover new molecules by genome mining and investigate their physiological role
Glycosylation of S-layer proteins and role in the tolerance of bacteria towards metals end radionucleides
Metabolomics and applications in ecotoxicological studies
Proteomics applied to archeozoology
Publications
2023
- , 2023 — Molecular acclimation of Halobacterium salinarum to halite brine inclusions. Frontiers in Microbiology. Vol. 13, p. 1075274.ISSN:1664-302X
2022
- , 2022 — Impact of microcin J25 on the porcine microbiome in a continuous culture model. Frontiers in Microbiology. Vol. 13, p. 930392.ISSN:1664-302X
- , 2022 — Gastrointestinal Stability and Cytotoxicity of Bacteriocins From Gram-Positive and Gram-Negative Bacteria: A Comparative in vitro Study. Frontiers in Microbiology. Vol. 12, p. 780355.ISSN:1664-302X
- , 2022 — Effects of drinking water supplementation with Lactobacillus reuteri, and a mixture of reuterin and microcin J25 on the growth performance, caecal microbiota and selected metabolites of broiler chickens. Journal of Animal Science and Biotechnology. Vol. 13, p. 34.ISSN:2049-1891
2021
- , 2021 — Untangling the fibre ball: Proteomic characterization of South American camelid hair fibres by untargeted multivariate analysis and molecular networking. Journal of Proteomics. Vol. 231, p. 104040.ISSN:1874-3919
2020
- , 2020 — Palaeoproteomics gives new insight into early southern African pastoralism. Scientific Reports. Vol. 10, n° 1, p. 14427.ISSN:2045-2322
- , 2020 — Microcin J25 Exhibits Inhibitory Activity Against Salmonella Newport in Continuous Fermentation Model Mimicking Swine Colonic Conditions. Frontiers in Microbiology. Vol. 11, p. 988.ISSN:1664-302X
- , 2020 — Phenomic and genomic approaches to studying the inhibition of multiresistant Salmonella enterica by microcin J25. Environmental Microbiology. Vol. 22, n° 7, p. 2907-2920.ISSN:1462-2920
- , 2020 — Bacteriocins to Thwart Bacterial Resistance in Gram Negative Bacteria. Frontiers in Microbiology. Vol. 11.ISSN:1664-302X
2019
- , October 2019 — Animal fibre use in the Keriya valley (Xinjiang, China) during the Bronze and Iron Ages: A proteomic approach. Journal of Archaeological Science. Vol. 110, p. 104996.ISSN:0305-4403